Grand Challenges in the Immunology of HIV and AIDS

Abstract

IntroductIon After the first reports of patients with AIDS in 1981, the discovery in 1983 of HIV as the etiological agent that causes AIDS and in 1984 of the CD4 protein as the main receptor for the virus our views on HIV pathology have been quite straightforward. Apparently HIV infects CD4+ human cells, which are mainly T helper cells, and in vitro studies… (More)
DOI: 10.3389/fimmu.2011.00020

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