Gramine Derivatives Targeting Ca(2+) Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases.

@article{LajarnCuesta2016GramineDT,
  title={Gramine Derivatives Targeting Ca(2+) Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases.},
  author={Roc{\'i}o Lajar{\'i}n-Cuesta and Carmen Nanclares and Juan-Alberto Arranz-Tagarro and Laura Gonz{\'a}lez-Lafuente and Raquel L Arribas and Monique Araujo de Brito and Luis M. Gandia and Crist{\'o}bal de Los R{\'i}os},
  journal={Journal of medicinal chemistry},
  year={2016},
  volume={59 13},
  pages={6265-80}
}
We describe the synthesis of gramine derivatives and their pharmacological evaluation as multipotent drugs for the treatment of Alzheimer's disease. An innovative multitarget approach is presented, targeting both voltage-gated Ca(2+) channels, classically studied for neurodegenerative diseases, and Ser/Thr phosphatases, which have been marginally aimed… CONTINUE READING