Gramicidin channels

  title={Gramicidin channels},
  author={O S Andersen and R. E. Koeppe and B. Roux},
  journal={IEEE Transactions on NanoBioscience},
Gramicidin channels are mini-proteins composed of two tryptophan-rich subunits. The conducting channels are formed by the transbilayer dimerization of nonconducting subunits, which are tied to the bilayer/solution interface through hydrogen bonds between the indole NH groups and the phospholipid backbone and water. The channel structure is known at atomic resolution and the channel's permeability characteristics are particularly well defined: gramicidin channels are selective for monovalent… CONTINUE READING
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Spatial structure of a gramicidin A transmembrane ion channel. NMR analysis in micelles

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