Gramicidin, valinomycin, and cation permeability of Streptococcus faecalis.

  title={Gramicidin, valinomycin, and cation permeability of Streptococcus faecalis.},
  author={Franklin M. Harold and J R Baarda},
  journal={Journal of bacteriology},
  volume={94 1},
Gramicidin and valinomycin in concentrations of 10(-7) and 10(-6)m, respectively, inhibited the growth of Streptococcus faecalis. Inhibition of growth was associated with loss of Rb(+) and K(+) from the cells, and could be reversed by addition of excess K(+). Cells treated with these antibiotics exhibited greatly increased permeability to certain cations; no effect was observed on the penetration of other small molecules. Unlike normal cells, cells treated with gramicidin rapidly lost internal… CONTINUE READING

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