Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions.

@article{Fischer2011GramSS,
  title={Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions.},
  author={M. Fischer and H. Kaehlig and W. Schmid},
  journal={Chemical communications},
  year={2011},
  volume={47 23},
  pages={
          6647-9
        }
}
  • M. Fischer, H. Kaehlig, W. Schmid
  • Published 2011
  • Chemistry, Medicine
  • Chemical communications
  • An efficient gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate (FHAP) has been developed. As a close analog to dihydroxyacetone phosphate, FHAP was used as a novel donor substrate for rabbit muscle aldolase catalyzed reactions. The different binding affinities of the gem-diol and keto form of FHAP were studied by (19)F-NMR. 
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