Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides.

@article{Malanovic2016GrampositiveBC,
  title={Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides.},
  author={Nermina Malanovic and K. A. Lohner},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1858 5},
  pages={936-46}
}
A number of cationic antimicrobial peptides, effectors of innate immunity, are supposed to act at the cytoplasmic membrane leading to permeabilization and eventually membrane disruption. Thereby, interaction of antimicrobial peptides with anionic membrane phospholipids is considered to be a key factor in killing of bacteria. Recently, evidence was provided that killing takes place only when bacterial cell membranes are completely saturated with peptides. This adds to an ongoing debate, which… CONTINUE READING

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