Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial–mesenchymal transition

@inproceedings{Pifer2016Grainyheadlike2I,
  title={Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial–mesenchymal transition},
  author={Phillip M Pifer and Joshua C. Farris and A. Luger Thomas and Peter Stoilov and James Denvir and David M. Smith and Steven M. Frisch},
  booktitle={Molecular biology of the cell},
  year={2016}
}
Developmental morphogenesis and tumor progression require a transient or stable breakdown of epithelial junctional complexes to permit programmed migration, invasion, and anoikis resistance, characteristics endowed by the epithelial-mesenchymal transition (EMT). The epithelial master-regulatory transcription factor Grainyhead-like 2 (GRHL2) suppresses and reverses EMT, causing a mesenchymal-epithelial transition to the default epithelial phenotype. Here we investigated the role of GRHL2 in… CONTINUE READING
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