Grafting protein ligand monolayers onto the surface of microparticles for probing the accessibility of cell surface receptors.

@article{Frey1999GraftingPL,
  title={Grafting protein ligand monolayers onto the surface of microparticles for probing the accessibility of cell surface receptors.},
  author={Andreas Frey and Barbara Meckelein and M Alexander Schmidt},
  journal={Bioconjugate chemistry},
  year={1999},
  volume={10 4},
  pages={
          562-71
        }
}
Coupling of a specific ligand to vaccines or drugs can be a powerful aid to route these compounds to a certain target cell population. However, if the targeted receptor is buried in a glycocalyx, binding of the ligand may be sterically hindered or even abolished, especially when the ligand is attached to bulky payloads. The antigen-transporting M cells that cover the gut-associated lymphoid tissue have a less pronounced glycocalyx than neighboring enterocytes. Such architectural differences… CONTINUE READING
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