Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA.

@article{Kano2011GraftingOP,
  title={Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA.},
  author={Arihiro Kano and Kenji Moriyama and Takeshi Yamano and Izumi Nakamura and Naohiko Shimada and Atsushi Maruyama},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2011},
  volume={149 1},
  pages={2-7}
}
Poly-lysine has been studied as a carrier for the delivery of drugs and nucleic acids for at least a decade. It is an especially attractive carrier for DNA and RNA, because of its condensed cationic charges. In our previous study, we showed that poly(ethylene glycol) (PEG) grafted to poly-L-lysine (PLL) remarkably increased the life time of a small interfering RNA (siRNA) in blood circulation. In this study, we prepared a new series of PEG-grafted PLL (PLL-g-PEG) with various lengths (PEG 2kDa… CONTINUE READING

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References

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Showing 1-10 of 18 references

Evolving lipid-based delivery systems in the management of neoplastic disease

  • I. Shapira, D. R. Budman, T. Bradley, R. Gralla
  • Oncology Reviews 3(2)
  • 2009
1 Excerpt

G

  • L. Barzon, A. L. Stefani, M. Pacenti
  • Pal√π, Versatility of gene therapy vectors…
  • 2005
1 Excerpt

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