Grafting T cells with tumor specificity: the chimeric receptor strategy for use in immunotherapy of malignant diseases.


Appreciation of the complementary nature of T-cell- and antibody-based immunotherapy stimulated interest in developing approaches that combine their advantages and minimize their limitations. A recent strategy is based on permanent grafting of cytotoxic T cells with a recombinant chimeric receptor designed for cellular targeting with antibody-like… (More)