Grafted granule and Purkinje cells can migrate into the mature cerebellum of normal adult rats

@article{Kawamura1988GraftedGA,
  title={Grafted granule and Purkinje cells can migrate into the mature cerebellum of normal adult rats},
  author={Koki Kawamura and T. Nanami and Yoshiaki Kikuchi and A. Kitakami},
  journal={Experimental Brain Research},
  year={1988},
  volume={70},
  pages={477-484}
}
Cerebellar primordia of different ages (embryonic days of 14 to 20) were transplanted into cerebella of normal syngeneic adult rats (Fischer 344). After 1–12 months (mostly 5–6 months), the host brains were examined by light and electron microscopy. In about 80% of our successful experiments, grafted Purkinje and/or granule cells migrated into the host molecular layer. Some granule cells migrated down along host Bergmann glia, reminiscent of their normal developmental migration route. Other… CONTINUE READING

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