Graft-vs.-host reactions: mechanisms and contemporary theories.

  title={Graft-vs.-host reactions: mechanisms and contemporary theories.},
  author={Herman Bril and Robbert Benner},
  journal={Critical reviews in clinical laboratory sciences},
  volume={22 1},
A graft-vs.-host (GvH) reaction can be initiated by injection of immunocompetent lymphocytes into a histoincompatible host that is unable to reject these cells. The reaction is characterized by splenomegaly, hepatomegaly, lymph node atrophy, body weight loss, dermatitis, and diarrhea, often leading to mortality. The onset and severity of the GvH reaction are determined by differences in histocompatibility antigens between the donor and the acceptor, and by the number and nature of the… CONTINUE READING

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