Graft versus neuroblastoma reaction is efficiently elicited by allogeneic bone marrow transplantation through cytolytic activity in the absence of GVHD

@article{Ash2009GraftVN,
  title={Graft versus neuroblastoma reaction is efficiently elicited by allogeneic bone marrow transplantation through cytolytic activity in the absence of GVHD},
  author={Shifra Ash and Vered Gigi and Nadir Askenasy and Ina Fabian and Jerry Stein and Isaac Yaniv},
  journal={Cancer Immunology, Immunotherapy},
  year={2009},
  volume={58},
  pages={2073-2084}
}
Continuous efforts are dedicated to develop immunotherapeutic approaches to neuroblastoma (NB), a tumor that relapses at high rates following high-dose conventional cytotoxic therapy and autologous bone marrow cell (BMC) reconstitution. This study presents a series of transplant experiments aiming to evaluate the efficacy of allogeneic BMC transplantation. Neuro-2a cells were found to express low levels of class I major histocompatibility complex (MHC) antigens. While radiation and syngeneic… CONTINUE READING

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