Graft versus leukemia response without graft-versus-host disease elicited by adoptively transferred multivirus-specific T-cells.

@article{Melenhorst2015GraftVL,
  title={Graft versus leukemia response without graft-versus-host disease elicited by adoptively transferred multivirus-specific T-cells.},
  author={Jan Joseph Melenhorst and Paul Castillo and Patrick J. Hanley and Michael D. Keller and Robert A. Krance and Judith Frances Margolin and Ann M. Leen and Helen E Heslop and A. J. Barrett and Cliona M Rooney and Catherine M. Bollard},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2015},
  volume={23 1},
  pages={179-83}
}
A 12-year-old boy with refractory acute lymphoblastic leukemia received a haploidentical transplant from his mother. As prophylaxis for Epstein-Barr virus (EBV), cytomegalovirus (CMV) and adenovirus, he received ex vivo expanded virus-specific donor T cells 3.5 months after transplant. Four weeks later leukemic blasts bearing the E2A deletion, identified by… CONTINUE READING