Graft-versus-leukemia effects of transplantation and donor lymphocytes.

@article{Kolb2008GraftversusleukemiaEO,
  title={Graft-versus-leukemia effects of transplantation and donor lymphocytes.},
  author={Hans-Jochem Kolb},
  journal={Blood},
  year={2008},
  volume={112 12},
  pages={
          4371-83
        }
}
  • H. Kolb
  • Published 1 December 2008
  • Biology, Medicine
  • Blood
Allogeneic transplantation of hematopoietic cells is an effective treatment of leukemia, even in advanced stages. Allogeneic lymphocytes produce a strong graft-versus-leukemia (GVL) effect, but the beneficial effect is limited by graft-versus-host disease (GVHD). Depletion of T cells abrogates GVHD and GVL effects. Delayed transfusion of donor lymphocytes into chimeras after T cell-depleted stem cell transplantation produces a GVL effect without necessarily producing GVHD. Chimerism and… 
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TLDR
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The data for ACT of leukemia is summarized for physicians in-training and in practice and for investigators who work in this and related fields as there are recent discoveries already being translated to the patient setting and numerous accruing clinical trials.
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