Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia.

@article{Rezvani2007GraftversusleukemiaEA,
  title={Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia.},
  author={K Rezvani and Agnes S. M. Yong and Bipin N Savani and Stephan Mielke and Keyvan Keyvanfar and Emma Gostick and David A. Price and Daniel C. Douek and A. J. Barrett},
  journal={Blood},
  year={2007},
  volume={110 6},
  pages={1924-32}
}
To determine whether the leukemia-associated Wilms tumor antigen (WT1) contributes to a graft-versus-leukemia (GVL) effect after allogeneic stem-cell transplantation (SCT) for acute lymphoblastic leukemia (ALL), we studied CD8(+) T-cell responses to WT1 in 10 human lymphocyte antigen (HLA)-A*0201-positive ALL patients during the early phase of immune recovery after SCT (days 30-120). Seven of 10 patients had detectable WT1 expression in their peripheral blood (PB) before SCT by quantitative… CONTINUE READING

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