Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells.

@article{Li2011GraftversushostDI,
  title={Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells.},
  author={Hongmei Li and Catherine Matte-Martone and Hung Sheng William Tan and Srividhya Venkatesan and Jennifer Madison McNiff and Anthony Jake Demetris and D Jain and Fadi G Lakkis and David Michael Rothstein and Warren D Shlomchik},
  journal={Journal of immunology},
  year={2011},
  volume={186 1},
  pages={
          230-41
        }
}
Graft-versus-host disease (GVHD) is initiated by APCs that prime alloreactive donor T cells. In antipathogen responses, Ag-bearing APCs receive signals through pattern-recognition receptors, including TLRs, which induce the expression of costimulatory molecules and production of inflammatory cytokines, which in turn mold the adaptive T cell response. However, in allogeneic hematopoietic stem cell transplantation (alloSCT), there is no specific pathogen, alloantigen is ubiquitous, and signals… CONTINUE READING
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