Graft-versus-host disease in limb transplantation: digital image analysis of bone marrow and TGF-beta expression in situ using a novel 3-D microscope.

@article{Ramsamooj1996GraftversushostDI,
  title={Graft-versus-host disease in limb transplantation: digital image analysis of bone marrow and TGF-beta expression in situ using a novel 3-D microscope.},
  author={Rajendra Ramsamooj and Ramon Llull and Linda Tatem and Kirby S Black and V Lotano and Robert Dalsey and Christopher T. Born and William G Delong and Charles W. Hewitt},
  journal={Transplantation proceedings},
  year={1996},
  volume={28 4},
  pages={2029-31}
}
A subpopulation of parental to hybrid VBMT recipients developed characteristic clinical and histopathologic manifestations of GVHD. These changes are similar to those seen in human GVHD secondary to bone marrow transplantation. Human GVHD also manifests itself in an acute and chronic manner. Only a minority (30% to 40%) of animals developed lethal GVHD in… CONTINUE READING