Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins.

@article{Eriguchi2012GraftversushostDD,
  title={Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins.},
  author={Yoshihiro Eriguchi and Shuichiro Takashima and Hideyo Oka and Sonoko Shimoji and Kiminori Nakamura and Hidetaka Uryu and Shinji Shimoda and Hiromi Iwasaki and Nobuyuki Shimono and Tokiyoshi Ayabe and Koichi Akashi and Takanori Teshima},
  journal={Blood},
  year={2012},
  volume={120 1},
  pages={223-31}
}
Allogeneic hematopoietic stem cell transplantation (SCT) is a curative therapy for various hematologic disorders. Graft-versus-host disease (GVHD) and infections are the major complications of SCT, and their close relationship has been suggested. In this study, we evaluated a link between 2 complications in mouse models. The intestinal microbial communities are actively regulated by Paneth cells through their secretion of antimicrobial peptides, α-defensins. We discovered that Paneth cells are… CONTINUE READING
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