Graft-versus-host disease and outcome in HLA-identical sibling transplantations for chronic myeloid leukemia.

@article{Gratwohl2002GraftversushostDA,
  title={Graft-versus-host disease and outcome in HLA-identical sibling transplantations for chronic myeloid leukemia.},
  author={Alois A Gratwohl and Ronald Brand and Jane F. Apperley and Anja v Biezen Av and G. Bandini and Agn{\'e}s Devergie and Anton V Schattenberg and Francesco Frassoni and Cesare Guglielmi and Simona Iacobelli and Mauricette Michallet and H Kolb and Tapani Ruutu and Dietger Niederwieser},
  journal={Blood},
  year={2002},
  volume={100 12},
  pages={3877-86}
}
Graft-versus-host disease in its acute (aGvHD) or chronic form (cGvHD) remains the most important posttransplantation factor influencing outcome after allogeneic hematopoietic stem cell transplantation (HSCT). It increases transplantation-related mortality (TRM) but reduces risk of relapse. The net effect of these 2 discordant effects determines survival. In view of current interests to exploit graft-versus-leukemia (GVL) effects, we analyzed 4174 HLA-identical sibling transplantations for… CONTINUE READING

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