Graft produced interleukin-6 functions as a danger signal and promotes rejection after transplantation.

@article{Liang2007GraftPI,
  title={Graft produced interleukin-6 functions as a danger signal and promotes rejection after transplantation.},
  author={Yurong Liang and Kenneth Christopher and Patricia W. Finn and Yolonda L Colson and David L. Perkins},
  journal={Transplantation},
  year={2007},
  volume={84 6},
  pages={771-7}
}
BACKGROUND Interleukin (IL)-6 is a pleiotropic cytokine that functions in both the innate and adaptive immune responses. However, the role of IL-6 in allograft rejection remains poorly understood. METHODS In this study, we demonstrate a critical role for graft-produced IL-6 in allograft rejection in a murine model of cardiac allograft transplantation. RESULTS The results show that IL-6-deficient grafts transplanted into allogeneic wild-type recipients have significantly prolonged survival… CONTINUE READING