Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.

@article{Chaidos2012GraftIN,
  title={Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.},
  author={Aristeidis I Chaidos and Scott Patterson and Richard M. Szydlo and Mohammed Suhail Chaudhry and Francesco Dazzi and Edward J Kanfer and Donald Mcdonald and D. W. Marin and Dragana Milojkovic and Jiř{\'i} Pavlů and John Y Davis and Amin Rahemtulla and Katy Rezvani and John Goldman and Irene A. G. Roberts and Jane F. Apperley and Anastasios Karadimitris},
  journal={Blood},
  year={2012},
  volume={119 21},
  pages={
          5030-6
        }
}
Invariant natural killer T (iNKT) cells are powerful immunomodulatory cells that in mice regulate a variety of immune responses, including acute GVHD (aGVHD). However, their clinical relevance and in particular their role in clinical aGVHD are not known. We studied whether peripheral blood stem cell (PBSC) graft iNKT-cell dose affects on the occurrence of clinically significant grade II-IV aGVHD in patients (n = 57) undergoing sibling, HLA-identical allogeneic HSCT. In multivariate analysis… CONTINUE READING

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