Graft failure after T-cell-depleted human leukocyte antigen identical marrow transplants for leukemia: I. Analysis of risk factors and results of secondary transplants.

@article{Kernan1989GraftFA,
  title={Graft failure after T-cell-depleted human leukocyte antigen identical marrow transplants for leukemia: I. Analysis of risk factors and results of secondary transplants.},
  author={Nancy A Kernan and Claudio Bordignon and Glenn Heller and Isabel Cunningham and Hugo Castro-Malaspina and Brenda Shank and Neal Flomenberg and Julie Burns and S Y Yang and Perry Black},
  journal={Blood},
  year={1989},
  volume={74 6},
  pages={2227-36}
}
Risk factors for graft failure were analyzed in 122 recipients of an allogeneic T-cell-depleted human leukocyte antigen (HLA)-identical sibling marrow transplant as treatment for leukemia. In each case pretransplant immunosuppression included 1,375 to 1,500 cGy hyperfractionated total body irradiation and cyclophosphamide (60 mg/kg/d x 2). No patient received immunosuppression prosttransplant for graft-versus-host disease (GVHD) prophylaxis. Nineteen patients in this group experienced graft… CONTINUE READING

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