Gradual transition from mosaic to global DNA methylation patterns during deuterostome evolution

@inproceedings{Okamura2010GradualTF,
  title={Gradual transition from mosaic to global DNA methylation patterns during deuterostome evolution},
  author={Kohji Okamura and Kazuaki A. Matsumoto and Kenta Nakai},
  booktitle={BMC Bioinformatics},
  year={2010}
}
DNA methylation by the Dnmt family occurs in vertebrates and invertebrates, including ascidians, and is thought to play important roles in gene regulation and genome stability, especially in vertebrates. However, the global methylation patterns of vertebrates and invertebrates are distinctive. Whereas almost all CpG sites are methylated in vertebrates, with the exception of those in CpG islands, the ascidian genome contains approximately equal amounts of methylated and unmethylated regions… CONTINUE READING
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