Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody.

@article{Rosrio2008GradualDI,
  title={Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody.},
  author={Ana Paula Freitas do Ros{\'a}rio and Sandra M{\'a}rcia Muxel and S{\'e}rgio Marcelo Rodr{\'i}guez-M{\'a}laga and Luiz Roberto Sardinha and Cl{\'a}udia Augusta Zago and Sheyla In{\'e}s Castillo-M{\'e}ndez and Jos{\'e} Maria {\'A}lvarez and Maria Regina D'Imp{\'e}rio Lima},
  journal={Journal of immunology},
  year={2008},
  volume={181 12},
  pages={8344-55}
}
The mechanisms responsible for the generation and maintenance of immunological memory to Plasmodium are poorly understood and the reasons why protective immunity in humans is so difficult to achieve and rapidly lost remain a matter for debate. A possible explanation for the difficulty in building up an efficient immune response against this parasite is the massive T cell apoptosis resulting from exposure to high-dose parasite Ag. To determine the immunological mechanisms required for long-term… CONTINUE READING
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