Gradual adaptive changes of a protein facing high salt concentrations.

  title={Gradual adaptive changes of a protein facing high salt concentrations.},
  author={Nicolas Coquelle and Romain Talon and Douglas H Juers and Eric Girard and Richard Kahn and Dominique Madern},
  journal={Journal of molecular biology},
  volume={404 3},
Several experimental techniques were applied to unravel fine molecular details of protein adaptation to high salinity. We compared four homologous enzymes, which suggested a new halo-adaptive state in the process of molecular adaptation to high-salt conditions. Together with comparative functional studies, the structure of malate dehydrogenase from the eubacterium Salinibacter ruber shows that the enzyme shares characteristics of a halo-adapted archaea-bacterial enzyme and of non-halo-adapted… CONTINUE READING

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