Grading of soft tissue sarcomas: from histological to molecular assessment.

@article{Neuville2014GradingOS,
  title={Grading of soft tissue sarcomas: from histological to molecular assessment.},
  author={Agn{\`e}s Neuville and Fr{\'e}d{\'e}ric Chibon and Jean-Michel Coindre},
  journal={Pathology},
  year={2014},
  volume={46 2},
  pages={
          113-20
        }
}
Several histological grading systems for soft tissue sarcomas have been described since the early 1980s. Their main objective is to select patients for adjuvant chemotherapy. Two histological grading systems are used in daily practice, the National Cancer Institute (NCI) and the French Federation of Cancer Centers Sarcoma Group (FNCLCC) systems. They have been devised by combining histological parameters: number of mitoses per high-power field, the presence of necrosis, cellular and nuclear… 

The Histopathological Grading Of Soft Tissue Sarcomas: A Review

TLDR
It is highlighted that histological STS grading is not without its limitations, not least in classifying 50% of tumours as of uncertain behaviour (grade 2), but recent developments in molecular risk stratification hold promise for molecular grading of STS with the ultimate goal of personalising therapy based on molecular profiles.

Significance of Ki-67 in prognostication of soft tissue tumors

TLDR
It can be recommended that Ki-67 IHC stain should be done on routine basis to accurately grade the sarcomas so that it will be beneficia l for the management of the patient.

What morphological MRI features enable differentiation of low-grade from high-grade soft tissue sarcoma?

TLDR
A diagnostic MRI score based on tumour heterogeneity, intratumoural and peritumoural enhancement enables identification of lesions that are likely to be high-grade as opposed to low-grade STS.

The clinician's perspective on sarcoma pathology reporting: impact on treatment decisions?

Summary The current refinement of nosological classification of sarcoma which integrates molecular typing with a growing number of subtypes contrasts with the one-size-fits-all approach proposed in

The surgical management of head and neck sarcoma: The Newcastle experience.

Gross examination and reporting of soft tissue tumours: evaluation of compliance with the UK Royal College of Pathologists soft tissue sarcoma dataset

TLDR
While essential information was always included in reports, more specific details contributing to better quality reports such as more detailed macroscopic descriptions and a higher proportion of clinical summaries with radiological correlation were included in 2011 than 2006, despite increasing workload.

Morphology, molecular genetics and multidisciplinary management: soft tissue pathology in 2014 and beyond.

TLDR
This issue Vickie Jo and Chris Fletcher summarise the significant changes in the recently published 4th edition of the WHO classification, including new immunohistochemical markers which may assist with diagnosis, as well as elaborating new information which has come to light since that classification appeared (highlighting soft tissue pathology as a rapidly evolving area).

Soft Tissue Sarcoma

TLDR
The treatment of adolescent and young adult patients with soft tissue sarcomas is particularly complex and necessarily w and requires adequate expertise and Cooperation between pediatric oncologists and adult oncologist is of critical importance.
...

References

SHOWING 1-10 OF 71 REFERENCES

Grading in soft tissue tumors: principles and problems

TLDR
This article summarizes and critically analyzes the various important grading systems that have thus far been proposed and suggests alternatives for the elaboration of more reproducible systems with higher predictive capabilities.

Problems in grading soft tissue sarcomas.

TLDR
There is no consensus as to the best grading system, and even those schemes that are most widely applied (those of the French National Cancer Centers and the National Cancer Institute in the United States) have important and acknowledged limitations.

Grading of soft tissue sarcomas: review and update.

  • J. Coindre
  • Medicine
    Archives of pathology & laboratory medicine
  • 2006
TLDR
Grading is the best predictor of metastasis outcome in adult soft tissue sarcomas and should be part of the pathologic report and adapted to the modern management of patients and complemented by radiologic and molecular parameters.

Grading of soft tissue sarcomas: the challenge of providing precise information in an imprecise world

By identifying patients at greatest risk for distant metastasis and, hence, most likely to benefit from adjuvant therapy, the grading of sarcomas has been one of the most important contributions

Reproducibility of a histopathologic grading system for adult soft tissue sarcoma

TLDR
The tumor grading system developed inside the French Federation of Cancer Centers, although perfectible, already provides reliable prognostic information and its use in prospective clinical studies may provide more information about its clinical usefulness.

Soft‐tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system

TLDR
A second multivariate analysis introducing clinical prognostic features showed that the histological grade was the most important prognostic factor for soft‐tissue sarcomas and appears to be highly interesting because of its prognostic value and the facility of its elaboration.

The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases

TLDR
The results of the stratified analyses show that necrosis is the single best histopathologic parameter to predict the time to recurrence and the overall survival of the patients and the value of necrosis in the primary lesions predicting the clinical course after recurrence appears to be independent of age, sex, location, and size of the tumor.

A clinical and pathological staging system for soft tissue sarcomas

TLDR
The staging system now can be used for case evaluation for therapy determination and for intercomparison of series of patients as to incidence of different kinds of tumors, effects of treatment, and survival.
...