Grading inaccuracies in diagnostic biopsies revealing prostatic adenocarcinoma: implications for definitive radiation therapy.


PURPOSE A critical determinant of prognosis in prostate cancer is grade of disease. Historically, this has been determined by biopsy of the prostate using transperineal, transrectal, or transurethral approaches. Several reports in the literature reveal that these biopsies often underestimate the histologic grade of the tumor when compared with subsequent… (More)


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