Gradients of monoamine metabolites and cortisol in cerebrospinal fluid of psychiatric patients and healthy controls.

Abstract

Amine metabolites and cortisol were measured in four consecutive 3 ml samples of lumbar cerebrospinal fluid (CSF). There were pronounced concentration gradients for both 5-hydroxyindoleacetic acid and homovanillic acid, and there was no difference in the gradients of 11 controls and 17 psychiatric patients (10 depressed). As there was a close correlation between the mean of the first two fractions and the mean of all four fractions, a concentration obtained in 6 ml can be used to calculate that in a 12 ml CSF sample. In psychiatric patients there was a slight, but statistically significant concentration gradient for 3-methoxy-4-hydroxyphenylglycol (unconjugated as well as conjugated). No gradient was found for cortisol in CSF.

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@article{Bertilsson1982GradientsOM, title={Gradients of monoamine metabolites and cortisol in cerebrospinal fluid of psychiatric patients and healthy controls.}, author={Leif Bertilsson and Marie {\AA}sberg and Outi Lantto and Gianpaolo Scalia-Tomba and Lil Tr{\"a}skman-Bendz and Gunnel Tybring}, journal={Psychiatry research}, year={1982}, volume={6 1}, pages={77-83} }