Gradients, waves and timers, an overview of limb patterning models.

  title={Gradients, waves and timers, an overview of limb patterning models.},
  author={Irene L{\'o}pez Delgado and Miguel Torres},
  journal={Seminars in cell & developmental biology},
The vertebrate limb represents one of the oldest and most studied models in developmental and regenerative biology. Starting with classical experimental embryology and regenerative studies, its relevance in understanding biological mechanisms has expanded through the molecular biology era and now leads systems biology approaches in organogenesis. Limb patterning is organized along three main orthogonal axes; proximo-distal (P-D), antero-posterior (A-P) and dorso-ventral (D-V). Considerable… CONTINUE READING