Gradient steepness influences the pathfinding decisions of neuronal growth cones in vivo.

@article{Isbister2003GradientSI,
  title={Gradient steepness influences the pathfinding decisions of neuronal growth cones in vivo.},
  author={Carolyn M Isbister and Paul J. Mackenzie and Kenneth C W To and Timothy P. O'Connor},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 1},
  pages={193-202}
}
Gradients of chemotropic molecules are generally thought to be fundamental for the guidance of neuronal growth cones in the developing embryo. Here we show that the grasshopper-secreted semaphorin Sema 2a is expressed in a gradient during the period of tibial Ti1 pioneer axon pathfinding into the CNS. At two critical Ti1 growth cone choice points, the Sema… CONTINUE READING