Gradient sensing during chemotaxis.

  title={Gradient sensing during chemotaxis.},
  author={Tian Jin},
  journal={Current opinion in cell biology},
  volume={25 5},
Eukaryotic cells have the ability to sense chemoattractant gradients and to migrate toward the sources of attractants. The chemical gradient-guided cell movement is referred to as chemotaxis. Chemoattractants are detected by members of G-protein-coupled receptors (GPCRs) that link to heterotrimeric G-proteins. The GPCR/G-protein sensing machinery is able to translate external chemoattractants fields into intercellular cues, which direct reorganization of the actin cytoskeleton that drives cell… CONTINUE READING