Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import

@article{BenEfraim2001GradientOI,
  title={Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import},
  author={Iris Ben-Efraim and Larry Gerace},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={152},
  pages={411 - 418}
}
Nuclear import and export signals on macromolecules mediate directional, receptor-driven transport through the nuclear pore complex (NPC) by a process that is suggested to involve the sequential binding of transport complexes to different nucleoporins. The directionality of transport appears to be partly determined by the nucleocytoplasmic compartmentalization of components of the Ran GTPase system. We have analyzed whether the asymmetric localization of discrete nucleoporins can also… CONTINUE READING
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