Gradient model describes the spatial-temporal expression pattern of Hoxa genes in the developing vertebrate limb.


Pattern formation of the developing vertebrate limb is mainly controlled by the zone of polarizing activity (ZPA) and the apical ectodermal ridge (AER) which may act as sources of diffusing morphogens. These sources are tightly interconnected and maintained by positive feedback and, together with the established role of Wnt7 a on the dorsal side of the bud… (More)


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