Graded response to GABA by native extrasynaptic GABA receptors.

  title={Graded response to GABA by native extrasynaptic GABA receptors.},
  author={Catarina E. L Lindquist and Bryndis Birnir},
  journal={Journal of neurochemistry},
  volume={97 5},
GABA is the main inhibitory neurotransmitter in the mammalian CNS. GABA in the brain is commonly associated with a fast, point-to-point form of signalling called synaptic transmission (phasic inhibition), but there is growing evidence that GABA participates in another, slower and more diffuse form of signalling often referred to as tonic inhibition. Unresolved questions regarding tonic neuronal inhibition concern activation and functional properties of extrasynaptic GABAA receptors (GABARex… CONTINUE READING
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