Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quantal [corrected] Ca2+release.

@article{Ionescu2006GradedRA,
  title={Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quantal [corrected] Ca2+release.},
  author={Lucian Ionescu and King-Ho Cheung and Horia Vais and Don-On Daniel Mak and Carl L White and J. Kevin Foskett},
  journal={The Journal of physiology},
  year={2006},
  volume={573 Pt 3},
  pages={645-62}
}
Modulation of cytoplasmic free Ca2+ concentration ([Ca2+]i) by receptor-mediated generation of inositol 1,4,5-trisphosphate (InsP3) and activation of its receptor (InsP3R), a Ca2+-release channel in the endoplasmic reticulum, is a ubiquitous signalling mechanism. A fundamental aspect of InsP3-mediated signalling is the graded release of Ca2+ in response to incremental levels of stimuli. Ca2+ release has a transient fast phase, whose rate is proportional to [InsP3], followed by a much slower one… CONTINUE READING

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