Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas.

@article{Dong2008GradedLO,
  title={Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas.},
  author={P. Duc Si Dong and Elayne Provost and Steven D. Leach and Didier Y. R. Stainier},
  journal={Genes & development},
  year={2008},
  volume={22 11},
  pages={1445-50}
}
The mechanisms regulating pancreatic endocrine versus exocrine fate are not well defined. By analyzing the effects of Ptf1a partial loss of function, we uncovered novel roles for this transcription factor in determining pancreatic fates. In a newly identified hypomorphic ptf1a mutant, pancreatic cells that would normally express ptf1a and become exocrine cells, express the endocrine marker Isl1, indicating a cell fate switch. Surprisingly, a milder reduction of Ptf1a leads to an even greater… CONTINUE READING

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