Graded Maximal Exercise Testing to Assess Mouse Cardio-Metabolic Phenotypes

  title={Graded Maximal Exercise Testing to Assess Mouse Cardio-Metabolic Phenotypes},
  author={J. M. Petrosino and Valerie J. Heiss and Santosh Kumar Maurya and Anuradha Kalyanasundaram and Muthu Periasamy and Richard A Lafountain and Jacob M. Wilson and Orlando P. Simonetti and Ouliana Ziouzenkova and Yann H{\'e}rault},
  booktitle={PloS one},
Functional assessments of cardiovascular fitness (CVF) are needed to establish animal models of dysfunction, test the effects of novel therapeutics, and establish the cardio-metabolic phenotype of mice. In humans, the graded maximal exercise test (GXT) is a standardized diagnostic for assessing CVF and mortality risk. These tests, which consist of concurrent staged increases in running speed and inclination, provide diagnostic cardio-metabolic parameters, such as, VO2max, anaerobic threshold… CONTINUE READING