Graded Control of Microtubule Severing by Tubulin Glutamylation

  title={Graded Control of Microtubule Severing by Tubulin Glutamylation},
  author={Max L. Valenstein and Antonina Roll-Mecak},
Microtubule-severing enzymes are critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles, and cilia where tubulin detyrosination, acetylation, and glutamylation are abundant. These modifications exhibit stereotyped patterns suggesting spatial and temporal control of microtubule functions. Using human-engineered and differentially modified microtubules we find that glutamylation is the main regulator of the hereditary spastic paraplegia microtubule severing… CONTINUE READING
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