Grade of chemotherapy-induced necrosis as a predictor of local and systemic control in 881 patients with non-metastatic osteosarcoma of the extremities treated with neoadjuvant chemotherapy in a single institution

@article{Bacci2005GradeOC,
  title={Grade of chemotherapy-induced necrosis as a predictor of local and systemic control in 881 patients with non-metastatic osteosarcoma of the extremities treated with neoadjuvant chemotherapy in a single institution},
  author={Gaetano Bacci and M. Cristina Mercuri and Alessandra Longhi and Stefano Ferrari and Franco Bertoni and Michela Versari and Piero Picci},
  journal={European journal of cancer},
  year={2005},
  volume={41 14},
  pages={2079-85}
}
To determine whether necrosis induced by pre-operative chemotherapy correlates with the rate of systemic and local relapse, may change the pattern of relapse and/or may modify the chance of success of post-relapse treatments, we evaluated 881 patients with non-metastatic osteosarcoma of the extremities treated with five different protocols of neoadjuvant chemotherapy and surgery at the same institution between 1983 and 1999. The 5-year disease-free survival (DFS) and overall survival (OS… CONTINUE READING

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