Gr64f Is Required in Combination with Other Gustatory Receptors for Sugar Detection in Drosophila

@article{Jiao2008Gr64fIR,
  title={Gr64f Is Required in Combination with Other Gustatory Receptors for Sugar Detection in Drosophila},
  author={Yuchen Jiao and Seok Jun Moon and Xiaoyue Wang and Qiuting Ren and Craig Montell},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={1797-1801}
}
The mechanisms by which the fruit fly Drosophila melanogaster detects sweet compounds are poorly understood; however, a subset of the family of 68 gustatory receptors (Grs) has emerged as the key receptors. These seven transmembrane receptors include Gr5a and at least one member of the six genes in the Gr64 cluster (Gr64a), which are expressed in sugar-responsive neurons. Disruption of Gr5a prevents the detection of trehalose [1-3], whereas mutation of Gr64a impairs the responses to sucrose… CONTINUE READING

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