Gr-1(high) CD11b+ cells suppress B cell differentiation and lupus-like disease in lupus-prone male mice.

@article{Trigunaite2013Gr1highCC,
  title={Gr-1(high) CD11b+ cells suppress B cell differentiation and lupus-like disease in lupus-prone male mice.},
  author={Abhishek Trigunaite and Ayesha Khan and Evan Der and Anne Devan ‐ Song and Sanjay Varikuti and T N J\orgensen},
  journal={Arthritis and rheumatism},
  year={2013},
  volume={65 9},
  pages={2392-402}
}
OBJECTIVE Systemic lupus erythematosus (SLE) develops much more readily in females than in males. Previous research has focused primarily on identifying mechanisms pertinent to the pathology in females. The aim of the current study was to delineate active protective mechanisms in males. We present evidence of a new male-associated mechanism of protection against the development of lupus-like disease in lupus-prone (NZB × NZW)F1 mice. METHODS We identified previously uncharacterized cellular… CONTINUE READING