Gq-linked NK(2) receptors mediate neurally induced contraction of human sigmoid circular smooth muscle.

@article{Cao2000GqlinkedNR,
  title={Gq-linked NK(2) receptors mediate neurally induced contraction of human sigmoid circular smooth muscle.},
  author={Weibiao Cao and Victor E Pricolo and Lingqiang Zhang and Jos{\'e} Behar and Piero Biancani and Michael T. Kirber},
  journal={Gastroenterology},
  year={2000},
  volume={119 1},
  pages={51-61}
}
BACKGROUND & AIMS Because tachykinins have been identified as neurotransmitters in the guinea pig colon and human ileum, we examined a possible role of tachykinin receptors and neurokinin (NK) A in neurally induced contraction of human sigmoid colon circular muscle. METHODS Muscle strips were stimulated electrically for 10 seconds. Single cells were isolated by enzymatic digestion and permeabilized by saponin. [(35)S]GTPgammaS binding was assayed with or without NKA for 5 minutes… CONTINUE READING

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