Gqα protein function in vivo: Genetic dissection of its role in photoreceptor cell physiology

@article{Scott1995GqPF,
  title={Gqα protein function in vivo: Genetic dissection of its role in photoreceptor cell physiology},
  author={Kristin Scott and Ann Becker and Yumei Sun and Robert Hardy and Charles S. Zuker},
  journal={Neuron},
  year={1995},
  volume={15},
  pages={919-927}
}
Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activated by Gq alpha in reconstituted systems. To determine whether a Gq-like protein couples rhodopsin to PLC, and to study its function, we isolated a mutant defective in a… CONTINUE READING
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