Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation.

@article{Mogha2013Gpr126FI,
  title={Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation.},
  author={Amit Mogha and Andrew E. Benesh and Chinmoy Patra and Felix B. Engel and Torsten Sch{\"o}neberg and Ines Liebscher and Kelly R Monk},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 46},
  pages={17976-85}
}
The myelin sheath surrounding axons ensures that nerve impulses travel quickly and efficiently, allowing for the proper function of the vertebrate nervous system. We previously showed that the adhesion G-protein-coupled receptor (aGPCR) Gpr126 is essential for peripheral nervous system myelination, although the molecular mechanisms by which Gpr126 functions were incompletely understood. aGPCRs are a significantly understudied protein class, and it was unknown whether Gpr126 couples to G… CONTINUE READING
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