Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome.

@article{Pellegrini1998Gpc3EC,
  title={Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome.},
  author={Mariagiuseppina Pellegrini and Giuseppe Pilia and Serafino Pantano and Franco Lucchini and Manuela Uda and M P Fumi and Asunci{\'o}n Cao and David Schlessinger and Antonino Forabosco},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1998},
  volume={213 4},
  pages={
          431-9
        }
}
Interest in glypican-3 (GPC3), a member of the glypican-related integral membrane heparan sulfate proteoglycans (GRIPS) family, has increased with the finding that it is mutated in the Simpson-Golabi-Behmel overgrowth syndrome (Pilia et al. [1996] Nat. Genet. 12:241-247). The working model suggested that the membrane-bound protein acts locally to limit tissue and organ growth and that it may function by interacting with insulin-like growth factor 2 (IGF2) to limit its local effective level… CONTINUE READING
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