GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice.

@article{Bhot2014GpIbVWFBR,
  title={GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice.},
  author={Audrey Le B{\'e}hot and Maxime Gauberti and Sara Martinez De Lizarrondo and Axel Montagne and Elo{\"i}se Lemarchand and Yohann Repess{\'e} and Sylvain S. Guillou and C{\'e}cile V. Denis and Eric Maubert and Cyrille Orset and Denis Vivien},
  journal={Blood},
  year={2014},
  volume={123 21},
  pages={3354-63}
}
Interactions between platelet glycoprotein (Gp) IIb/IIIa and plasma proteins mediate platelet cross-linking in arterial thrombi. However, GpIIb/IIIa inhibitors fail to disperse platelet aggregates after myocardial infarction or ischemic stroke. These results suggest that stability of occlusive thrombi involves additional and as-yet-unidentified mechanisms… CONTINUE READING