Governing step of metastasis visualized in vitro.

  title={Governing step of metastasis visualized in vitro.},
  author={Takashi Chishima and Ming Yang and Yohei Miyagi and Lingna Li and Yuying Tan and Eugene Baranov and Hiroyuki Shimada and Abdool R. Moossa and Sheldon Penman and Robert M Hoffman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 21},
Metastasis is the ultimate life-threatening stage of cancer. The lack of accurate model systems thwarted studies of the metastatic cell's basic biology. To follow continuously the succeeding stages of metastatic colony growth, we heritably labeled cells from the human lung adenocarcinoma cell line ANIP 973 with green fluorescent protein (GFP) by transfection with GFP cDNA. Labeled cells were then injected intravenously into nude mice, where, by 7 days, they formed brilliantly fluorescing… CONTINUE READING


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