Gout as autoinflammatory disease: new mechanisms for more appropriated treatment targets.

@article{Punzi2012GoutAA,
  title={Gout as autoinflammatory disease: new mechanisms for more appropriated treatment targets.},
  author={Leonardo Punzi and Adri{\`a} Mainar Scanu and Roberta Ramonda and Francesca Oliviero},
  journal={Autoimmunity reviews},
  year={2012},
  volume={12 1},
  pages={
          66-71
        }
}
Gout is probably one of the oldest diseases affecting men. This is not surprising especially for the active role that innate immunity seems to play in its pathogenesis. It is fascinating to observe as this ancestral mechanism of defense feels that microcrystals are a danger, quite similar to infectious agents. New advances have revealed that at the base of the powerful inflammatory reaction stimulated by monosodium urate crystals there are many complexes cellular mechanisms, mainly involving… CONTINUE READING
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