Gout: an evidence-based review.

@article{Chen2008GoutAE,
  title={Gout: an evidence-based review.},
  author={Lan X. Chen and H. Ralph Schumacher},
  journal={Journal of clinical rheumatology : practical reports on rheumatic \& musculoskeletal diseases},
  year={2008},
  volume={14 5 Suppl},
  pages={
          S55-62
        }
}
  • Lan X. Chen, H. Schumacher
  • Published 1 October 2008
  • Medicine, Psychology
  • Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
bout 1% of individuals studied in Western populations will develop gout during their lifetime. Gout has a well-understood pathogenesis and effective treatments, but re-mains suboptimally managed. 1–3 This review will emphasize recent developments related to gout epidemiology, pathogenesis, diagnosis, and efficacy of existing therapies. In each of these areas, we identify evidence, persisting gaps in evidence, and address clinical implications. 

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This short review covers general principles of the management of gout and then focuses on practical aspects and use of febuxostat.

Study on the diagnosis of gout with xanthine and hypoxanthine

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TLDR
Gout is increasingly recognized as a prevalent chronic disease state requiring appropriate long‐term management while controlling for risk factors and comorbid conditions, and effective treatment options can help gout patients achieve therapeutic SUA targets to control gout flares and prevent potentially destructive disease manifestations.

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An overview of the pathophysiology of gout is given and practice nurses can help patients understand gout and encourage lifestyle changes and treatment adherence.

A Systematic Review of the Economic and Humanistic Burden of Gout

TLDR
The evidence confirms that gout has a growing overall prevalence and represents a significant burden in terms of both direct healthcare cost and health-related quality of life (HRQL) outcomes.

Gout: No Longer the Disease of Kings

TLDR
Gout can lead to inflammation and damage to cartilage, bone, bursa, tendons, heart, or kidneys, and some people with gout will progress to chronic gout with tophi deposits, pain, deformity, and bone and cartilage destruction.

THE CLINICAL FEATURES AND TREATMENT METHODOLOGIES OF GOUT

TLDR
Gout is the most prevalent inflammatory arthritis and affects 2.5% of the general population in the UK, and is the only arthritis that has the potential to be cured with safe, inexpensive and well tolerated urate-lowering treatments, which reduce serum uric acid by either inhibiting xanthine oxidase – e.g. allopurinol or by increasing the renal excretion of uric Acid.

Rhazes viewpoints about causes, diagnosis, treatment and prognosis of gout

TLDR
Generally most of Rhazes viewpoints about gout are correct and compatible with recent findings and more investigation on Rhazes’ viewpoints can guide us to propose more reliable hypothesis and schematize cost effective studies by delving into past medical records.
...

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TLDR
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TLDR
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TLDR
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